Effect of captopril on plasma levels of neuropeptide Y (NPY)-like immunoreactivity in the pithed guinea pig

P Dahlöf, JM Lundberg, C Dahlöf - Neuropeptides, 1991 - Elsevier
The effect of exogenous angiotensin II (A II) and the angiotensin convertinng enzyme (ACE)-
inhibitor captopril on plasma levels of neuropeptide Y-like immunoreactivity (NPY-LI) has
been studied in the pithed guinea pig. Four periods of pre-ganglionic nerve stimulation
(PNS, 8Hz for 30s with 20 min intervals) were applied and the increases of mean arterial
blood pressure (ΔBP), heart rate (ΔHR) and plasma NPY-LI (ΔNPY-LI) in response to PNS
were analysed in non-pre-treated and captopril pre-treated animals. Captopril (5 mg× kg− 1 …
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